2013 - Volume 1 - Issue 1 Articles
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Perspective | ArticleJuly 03, 2013 | Pages : 205 - 450Abstract BRCA1-associated ATM activator-1 (BRAT1) was identified by our group as a DNA damage response (DDR) protein, which can bind with many DDR proteins and regulates their functions after DNA damage. However, previous study has also implicated BRAT1 as.....
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Review Article | ArticleBy Awad ShammaJuly 03, 2013 | Pages : 205 - 450Abstract The findings that the retinoblastoma tumor suppressor gene product (pRB) controls gene expression by physically interacting with several epigenetic regulators reveals another potential form of the RB functions in global regulation of the epigen.....
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Next Generation Epidemiology: The Bridge for Translational Cancer Research and Personalized MedicineEditorial | ArticleBy Zhenming FuJuly 05, 2013 | Pages : 205 - 450Abstract US biomedical research including epidemiology research has been criticized that a majority of the research findings are not translational. That is, researches have limited direct impact on improving patient care and public health [1]. In a move.....
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Research Article | ArticleJuly 07, 2013 | Pages : 205 - 450Abstract ATM, ATR and DNA-PK are critical for DNA damage response (DDR) and sequential repair, leading to genomic stability. In this study, we found the expression of these proteins is markedly induced by PMA during THP1 differentiation without the change .....
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Editorial | ArticleBy Jeremy ChienJuly 07, 2013 | Pages : 205 - 450Abstract Advances in genomic sequencing technologies and computational and analytical methods are now allowing us to characterize at single base-pair resolution of cancer genomes and amass an unprecedented amount of information. However, the gap between ge.....